Sylvana Krappatsch was born in Quedlinburg. She completed her dramatic training at the Konrad Wolf Film University of Babelsberg, before working at various theatres, including at Schauspiel Zürich from 2000 to 2005 and the Munich Kammerspiele from 2005 to 2015. She was voted Best Emerging Female Actor in 1996 by the trade journal Theatre heute. Krappatsch appears regularly in films, television and cinema. She joined the Schauspiel Stuttgart ensemble in the 2018/19 season.