Marco Massafra was born in Liestal in Switzerland and studied drama at the Otto Falckenberg School of Performing Arts in Munich. He was guest actor at the Residence Theatre of Munich and at the Bern Theatre, before becoming an ensemble member at Schauspielhaus Bochum. In 2010, he won the Bochum Theatre Prize for Best Emerging Artist. Massafra worked as a freelance actor and director from 2016. He joined the Schauspiel Stuttgart ensemble in the 2018/19 season.